Betamethasone is a glucocorticoid and has the general properties of corticosteroids. It acts by controlling the rate of proteinsynthesis.
Each ml contains:
Should be used with the following indications:
For parenteral use:
• Shock (burns, traumatic, operations, toxic, cardiogenic, blood transfusion, anaphylactic);
• Allergic reactions (acute, severe), anaphylactoid reactions;
• Brain swelling (brain tumor or associated with surgery, radiation therapy, or a head injury), increased intracranial pressure;
• Bronchial asthma (severe), asthma status;
• Systemic connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis);
• Acute adrenal insufficiency, prevention of adrenal insufficiency in patients who received corticosteroids for a long time;
• Thyrotoxic crisis, acute hepatitis, hepatic coma;
• Poisoning cauterizing liquids;
• Diphtheritic croup (in combination with an appropriate antimicrobial therapy).
For intra-articular administration:
• Rheumatoid arthritis, osteoarthritis, traumatic arthritis, osteochondritis, acute gouty arthritis;
• Diseases of the soft tissues (including bursitis, fibrositis, tendinitis, tenosynovitis, myositis).
Intravenously, intramuscularly, intra-articularly, intralesionally or by infusion in doses equivalent to 4 mg to 20 mg betamethasone.
It may also be used by local injection into soft tissue, in doses equivalent to 4 mg to 8 mg.
Dosage frequency and route of administration must be adjusted to the specific requirements of the patient, according to the disease, the severity of the condition, the response obtained and the patients tolerance to the product.
Gipotazon IV bolus or drip – slow:
Adults: 4-8 mg single dose (if necessary -20 mg), followed by a maintenance dosage 2-4 mg.
Gipotazon IM deep:
Adults:4-6 mg (9 mg) per day. Children – IM injection, 1 to 5 years – an initial dose of 2 mg, 6-12 years – 4 mg.
Intra-articular and periarticular (adults): large joints of 2-4 mg (9 mg), small 0.8-2 mg not more than 1 time in 3 weeks, and in the bursa of 2-3 mg; tendon sheath 0.4-1 mg; soft tissue 2-6 mg; VC intralesional 0.1 mg/cm2 (not more), not more than 2 mg per week, if necessary mixed with a local anesthetic (1% lidocaine, procaine).
Rapid intravenous injection of massive doses of corticosteroids may sometimes cause cardiovascular collapse, and injections should therefore be given slowly or by infusion.